Selected Publications
The stem cell–supporting small molecule UM171 triggers Cul3-KBTBD4–mediated degradation of ELM2 domain–harboring proteins
Žemaitis K, Ghosh S, Hansson J, Subramaniam A. Journal of Biological Chemistry. 299(5):104662.
Lysine-specific demethylase 1A restricts ex vivo propagation of human HSCs and is a target of UM171
Subramaniam A, Žemaitis K, Safaee Talkhoncheh M, Yudovich D, Bäckström A, Debnath S, Chen J, Jain MV, Galeev R, Gaetani M, Zubarev RA, Larsson J. Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171. Blood. 2020 Jun doi: 10.1182/blood.2020005827. Epub ahead of print. PMID: 32582923
Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations
Subramaniam A*, Sandén C, Moura-Castro L, Žemaitis K, Schmiderer L, Baudet A, Bäckström A, Arvidsson E, Hultmark S, Miharada N, Magnusson M, Paulsson K, Fioretos K, Larsson J*. Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations. Haematologica. 2022 Sep 1;107(9):2271-2275 (* Co-corresponding authors).
Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells
Subramaniam A, Talkhoncheh MS, Magnusson M and Larsson J. Endothelial protein C receptor (EPCR) expression marks human fetal liver hematopoietic stem cells. Haematologica. 2019, 104 (2): e47-e50.